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PI3K Inhibitor- clarientinc.com
The phosphoinositide 3-kinase (PI3K)/AKT1 pathway is acknowledged as a key component of cell survival.Activated by receptors or the small GTPase Ras,the various PI3K isoforms phosphorylate inositol lipids to form second messenger phosphoinositides. PI3K family members have long been accepted as oncogenes.
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PI3K Pathway- clarientinc.com
Activation of the phosphatidylinositol 3-kinase (PI3K)-AKT pathway, regulates many normal cellular processes which include cell proliferation, survival, and motility. For these same reasons, the PI3K pathway also plays an important oncogenic role in many cancer types. PI3K signaling pathways can be deregulated by a variety of mechanisms in human tumors.
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EML4-ALK- clarientinc.com
We have found a novel fusion product between the echinoderm microtubule-associated protein-like4 (EML4) and the anaplastic lymphoma kinase (ALK) in non-small cell lung cancers (NSCLCs). Tumors featuring EML4-ALK fusion constitute one subtype of NSCLC that might be highly sensitive to ALK inhibitors. Herein, we present results of a first large scale study of EML4-ALK fusion in lung cancers.
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